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| DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOPHYSICS |
The Department of Biochemistry and Molecular Biophysics encompasses research on the structure, chemistry and mechanisms of biological responses, reactions and pathways. Investigators are using experimental techniques such as X-ray crystallography, NMR, optical spectroscopy, thermodynamics and rapid kinetics in combination with computational modeling to unravel the molecular underpinnings of processes of relevance to health and disease (biochem.wustl.edu). New emphasis on single-molecule dissection of protein dynamics and reaction mechanisms achieves deeper understanding of molecular processes. High throughput screening of chemical libraries and synthetic medicinal chemistry to develop small molecule probes of biological systems add strength to our growing efforts toward experimental therapeutics and translational research.
Faculty in the Department of Biochemistry and Molecular Biophysics teach basic science courses in the medical school curriculum, including The Molecular Foundations of Medicine and Principles of Pharmacology. Advanced courses in Molecular Medicine (Bio 5326), Nucleic Acids and Protein Synthesis (Bio548), and Macromolecular Interactions (Bio5312) describe the principles of molecular interactions underlying the biology of health and disease. Students in the School of Medicine and the Graduate School of Arts & Sciences are eligible for these courses and may elect to pursue biomedical research under the direction of our faculty. A full listing of advanced courses topics can be found at biochem.wustl.edu/courses/index.html.
Our faculty members are engaged in a broad spectrum of biomedically relevant research areas, including nucleic acids structure and enzymology, mechanisms of protein folding, misfolding and aggregation, cellular mechanics and signaling across membranes, and hemostasis, thrombosis and vascular biology. The Department offers unique training opportunities at the crossroad of biochemistry, biophysics, systems biology, computational science and pharmacological sciences.
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Last Modification: 08/03/2009
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